Assistant Professor Cornell University College of Veterinary Medicine Ithaca, New York, United States
Presentation Description / Summary: Sinus node dysfunction is a clinically important cause of bradyarrhythmias in dogs and people, yet its underlying mechanisms remain poorly defined. This talk will review normal sinus node physiology and explore the relationship between the calcium and voltage clocks in sinus node function. New translational research using mouse models and canine patients will be presented, offering fresh insights into the pathophysiology of sinus node dysfunction and its clinical relevance for veterinary cardiology.
Learning Objectives:
Upon completion, participants will be able to describe the voltage and calcium clock mechanisms for spontaneous depolarization of the sinus node.
Upon completion, participants will be able to relate results from research in mouse models of sinus node dysfunction to treatment of clinical canine patients.
Upon completion, participants will be able to describe the importance of the sinus node protein VSNL1 in normal sinus node function.
