Professor and Director of Research Texas A&M University CANYON, Texas, United States
Presentation Description / Summary: For decades, our understanding of Mannheimia haemolytica and its role in bovine respiratory disease (BRD) has been framed by culture-based approaches. While invaluable, these methods have provided an incomplete and sometimes misleading view of pathogen diversity, transmission, and ecology. Recent advances in sequencing technologies now allow us to look beyond the culture plate, revealing unprecedented strain-level resolution and reshaping long-held assumptions about this pathogen. In this seminar, we will explore how metagenomics and targeted sequencing are rewriting the story of BRD, changing the paradigm of how we should view pathogens and microbial communities in the pathogenesis of this important disease. We will highlight critical new perspectives on Mannheimia—from uncovering hidden diversity to expanded perspectives on the ecology of this classical BRD agent. These insights not only advance our scientific understanding of BRD but also open new avenues for prevention, diagnosis, and treatment strategies.
Learning Objectives:
Participants will be able to describe limitations of culture-based methods for characterizing Mannheimia haemolytica and BRD pathogens.
Participants will be able to explain how sequencing approaches provide greater insight into microbial communities, and how this knowledge is changing our perspective on the casuses of bovine respiratory diseases.
Participants will be able to explain how metagenomic sequencing and targeted shotgun sequencing provide strain-level characterization of Mannheimia and other BRD pathogens, and how this affects understanding of disease prevention
