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ACVIM Resident Research Award Eligible
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Food Animal Internal Medicine

In Person Only

Clinical Disease and Its Impact on Drug Disposition in Ruminants

AAVPT Track

Thursday, June 11, 2026
11:15 AM - 12:15 PM PT
Location: Summit SCC, Room 342
CE: 1.0 Medical Hours
One Health

    Primary Presenter(s)

  • Danielle Mzyk, DVM, PhD, DACVCP

    Field Service Clinical Veterinarian
    North Carolina State University College of Veterinary Medicine
    Hillsborough, North Carolina, United States

Disclosure(s):
Danielle Mzyk, DVM, PhD, DACVCP: No financial relationships to disclose
Clinical disease can profoundly alter drug disposition in ruminants. This session will examine how common disease states including inflammation, dehydration, organ dysfunction, and alterations in gastrointestinal physiology can affect absorption, distribution, metabolism, and excretion of drugs in cattle, sheep, and goats. Emphasis will be placed on clinically relevant changes in pharmacokinetics and pharmacodynamics, with discussion of how disease-driven variability can influence therapeutic efficacy and drug residue avoidance in food-producing animals.

Learning Objectives:

  • Describe how common clinical disease states (e.g., inflammation, dehydration, hepatic or renal dysfunction) alter the pharmacokinetic processes of absorption, distribution, metabolism, and excretion in ruminants.
  • Apply knowledge of disease-related pharmacokinetic alterations to adjust drug dosing regimens and optimize therapeutic outcomes in clinically ill ruminant patients
  • Apply principles of altered drug disposition to adjust drug selection, dosing strategies, and withdrawal interval considerations in diseased food-producing ruminants to promote judicious drug use and residue avoidance.