Panel: Successfully Delivering Precision Medicine One Tumor at a Time

Presentation Description / Summary: Precision medicine, defined as therapeutic strategies informed by genetic and molecular profiling, is gaining traction in veterinary oncology. Its promise lies in delivering targeted interventions based on patient-specific characteristics, thereby improving clinical outcomes, minimizing empirical prescribing, and enhancing prognostic accuracy through biomarker identification. Despite its potential, its use remains constrained by cost and a requirement for new workflows, training and decision support tools to integrate seamlessly into the clinic. Additionally, over-interpretation of results remains an issue for veterinary practitioners as very little data exists to differentiate actionable genetic mutations from passenger mutation targets with no clinical benefit. Understanding the function of oncogenic drivers in a cancer-specific context will help inform biomarker discovery and appropriate application of precision medicine. Ethos Discovery, a non-profit incubator of scientific innovation, seeks to evolve the existing perspective regarding precision medicine in veterinary patients and to close the integration gap by leveraging our successfully recruiting prospective clinical trials to generate new knowledge that can increase the utility of precision medicine. In this presentation we will share our progress and review preliminary findings from the high-level evidence gathered from the Ethos-SOLID, PUSH and MIMIC clinical trials which suggests that there is more hope for patients than we were led to believe.