Cardiology Resident Auburn University Auburn, Alabama, United States
Abstract: Background – Renin-angiotensin-aldosterone system (RAAS) activity and serum galectin-3 (SG3) are altered in patients with many cardiac diseases. Neither have been evaluated in dogs with PDAs.
Hypothesis / Objectives – We compared RAAS and SG3 activity in PDA dogs and in controls and hypothesized that they would differ significantly between groups.
Animals – 40 client-owned dogs (20 with PDAs, 20 controls).
Methods – Observational, prospective study. Dogs had the following assessed: echocardiography, blood pressure, biochemistry profile, RAAS analytes (Ang 1-5, Ang 1-7, Ang II, Ang I, Ang III, aldosterone), and SG3. Median (range) or mean +/- SD were described, and student’s t-test or Wilcoxon rank sums tests were used for between-group comparisons. A P < 0.05 was considered significant.
Results – PDA dogs had larger diastolic left ventricular internal dimensions [LVIDdN = 2.2 (1.35 – 3.22)] and left atrial diameters [LADN = 1.7 (1.14 – 2.49)] than controls [LVIDdN = 1.525 (1.15-1.69), LADN =1.27 (1.03-1.39)]; all P < 0.001. Mitral E/e’ was significantly (P = 0.015) higher in PDA dogs (7.59 +/- 2.43) than controls (5.92 +/- 1.55) but was not correlated with LVIDdN (P = 0.595) or LADN (P = 0.639). SG3 was not different between groups (PDA = 103.92 pg/mL +/- 47.8, control = 106.76 pg/mL +/- 49.15, P = 0.854). No RAAS analytes were different between groups (all P > 0.3).
Conclusions and clinical importance – RAAS and SG3 were not altered in PDA dogs. RAAS-modulation may not aid cardiac reverse remodeling in young dogs with PDAs.
